Arterial ischemic stroke was defined as a new focal neurologic deficit that lasted 24 houres or longer.Stroke is relatively rare in children and incidence of cerebro vascular disease is 1.2 to 2.7 per 100000. all incidense of prothrombotic disorders in children with arterial ischemic stroke is stimated to be 20% to 50% in most studies.PROTEIN s is one cause of stroke in children.the pathogenesis of vascular occlusion in patients with PROTEIN s deficiency is not known.we present a case of a 6-year-old boy with a history of tonic clonic sizure within a prriod of 3 years.he subsequently developed right hemiparesis and aphsia.head magnetic resonance imaging revealed lacunar infarction.in lab finding he had low level of PROTEIN s.the patient was started on intravenous heparin and ptient completely improved.

Functional genomics has provided new opportunities to understand the fundamental aspects of biotic and abiotic stresses in plants. In this study, a comparative analysis on EST libraries of wheat and its wild relatives conducted to discover novel genes and transcriptional factors involved in drought tolerance. EST analysis revealed a significant increase in expression level of S-lik RNase in drought condition. Further analysis by qPCR indicated over-expression of this gene in anther of tolerant cultivars. RNases participate in vital cellular functions such as DNA replication, transcription, splicing, and control of translation. T2 family RNases have been implicated in nutrition, phosphate remobilization, selfincompatibility, senescence, and defense against pathogens. This is the first report on the effect of S-lik RNase at drought stress response in wheat and significant up regulation of this gene in wheat wild relative (Aegilops tauschii) and that emphasize on finding new effective genes from wild relative plants for stress tolerance.

Background: A cell requires energy to do its work. Mitochondria are the energy-producing machines of the cell. Uncoupling PROTEINs (UCPs) located in the inner mitochondrial membrane cause a proton leak from the intermembrane space to the matrix. Clearly, the changes in the proton gradient across the inner membrane affect ATP production. In this paper, the role of these PROTEINs in different tissues as well as peripheral and central nervous tissues has been reviewed.Methods: This study has reviewed 63 publications explaining the various functions of UCPs in different tissues using PubMed, Elsevier, NCBI and EBSCO databases.Findings: Several studies have shown that UCPs, based on the type of tissue, change the cell activity.Conclusion: Studies related to UCPs roles in the nervous system are mostly restricted to the in-vitro situations; thus more investigation seems to be needed to reveal the UCPs actions in the in-vivo conditions of physiologic and pathologic studies. These studies potentially can open some new therapeutic strategies and hopes to cure neurodegenerative diseases.

Bone gla PROTEIN and matrix gla PROTEIN are of common origin with evolutionary relation and have similar structural features and are functional in the formation of skeletal structures The present study have been evaluated the genes encoding vitamin k-dependant PROTEINs (VKDPs) expression at hatching time (0), 1, 3, 6, 10, 12, 14, 20, 30 and 50 in skeletal Persian sturgeon sturgeon (Acipenser persicusBordin, 1897). The results of quantitative real-time PCR showed that the transcripts of VKDPs genes including bone Gla PROTEIN (bgp) and matrix Gla PROTEIN (mgp ) were significantly up-regulated during the transition to the exogenous feeding, confirming the hypothesis about the relevance of the above-mentioned genes in chondrogenesis at early developmental stages. Maximal levels of bgp and mgp expression at juvenile stage, indicating the importance of these genes in the mineralization of the skeleton in sturgeons, although these genes are also expressed in other body tissues. This information can be considered as a reference for other studies evaluating the quality of larvae and the influence of rearing biotic and abiotic factors in the skeletogenesis of this sturgeon species and the occurrence of skeletal deformities.